switchbladeeyes

I like biology and state of mind because they seem the most like they could involve achievable fixes within the show's universe. Perhaps a combination of biology and state of mind could overcome vampirism permanently with no possible relapse (unless you're brought over again, I suppose). That would be interesting.

With biology, the drug in "The Fix" was effective though not permanent. In season 1 , Nat's nutritional experiments have impacts on Nick's vampirism. Maybe they're just weakening him… but isn't that the point? To weaken the vampire?

State of mind might be my favorite though. We see in season 3 that it is highly, highly effective. The issue is making a state of mind permanent (and perhaps Janette achieved it, though I'm not convinced, and the "how" was not clear.)

When you think about it, it's possible other vampires have regained humanity using their minds to permanently revert back to human, but this is unknown to other vampires because (1) any vampire that had made such a change would have every reason to keep it a secret, (2) the odds of a vampire encountering such a former vampire would be teeny considering they're just another human on a planet full of humans, and (3) their secret would die with them within a mortal lifetime.

Maybe it's a biological mechanism to turn someone into a vampire, but state of mind can overcome it. I'll need to think on this some more, but I like it.

I don't like a state of spiritual or moral downfall.

On the moral front, modern Nick is not a "bad person." He definitely once was a bad person and still often sees himself that way, but in the show's modern era, he just isn't.

Interestingly, within the universe, we know that even LaCroix (of ALL people) doesn't see spiritual or moral downfall as inherent to vampirism. Remember that "Sons of Belial" exorcism when he told Nick that Nick had goodness in him and god in him? (I mean, holy shit, can you believe LaCroix said those things?)

And maybe LaCroix's observations were true considering the exorcism succeeded. If those things are true—that Nick has "goodness" and "god" within him even as a vampire— then a state of moral or spiritual downfall is not where Nick's problem lies. I think that Nick believing that to do be the case may be part of the state of mind he's got to adjust if he's ever to cure himself.